Citrus flavonoids as a substitute for substitute zinc oxide in piglets – Swine abstracts

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Zinc oxide at pharmacological doses, together with completely different antibiotics, has been used prophylactically to scale back the incidence of gastrointestinal issues. These days, the rising concern about of bacterial resistance to antibiotics, has led to the prohibition of the prophylactic use of zinc oxide in diets for piglets within the EU. Since citrus flavonoids have antioxidant and anti inflammatory properties, that these compounds may develop into an appropriate different to the usage of zinc oxide at weaning. The target of this research was to guage the impact of supplementing citrus flavonoids and amoxicillin in changing the usage of zinc oxide along with a number of antibiotics in weanling piglets. A complete of 252 weaned pigs ([LargeWhite × Landrace] × Pietrain) have been distributed in line with physique weight (5.7 kg ± 0.76) into 18 pens (6 pens per food plan, 14 pigs/pen). Three experimental diets for the prestarter (0–14 d postweaning) and starter (15–35 d postweaning) interval have been ready: 1) Management: nonmedicated food plan; 2) ZnO: Management food plan supplemented with zinc oxide at 2500 mg/kg, amoxicillin at 0.3 mg/kg and apramycin at 0.1 mg/kg; 3) Flavonoid: Management food plan with the addition of a industrial citrus flavonoid extract at 0.3 mg/kg and amoxicillin at 0.3 mg/kg. Pig physique weight , common each day acquire, common each day feed consumption, and feed conversion ratio have been assessed on d7, d14, and d35. Samples of intestinal tissue, cecal content material, and serum have been collected of 18 piglets on day seven.


Flavonoid therapy achieved higher physique weight and common each day acquire in the course of the starter and for the whole experimental interval in contrast with the management food plan, whereas ZnO pigs evidenced intermediate outcomes. Jejunum tissue evaluation confirmed that pigs fed the flavonoid food plan overexpressed genes associated to barrier perform, digestive enzymes, and nutrient transport in comparison with these pigs fed the management food plan. A rise within the abundance of bacterial genera similar to Succinivibrio, Turicibacter, and Mitsuokella was noticed within the flavonoid in contrast with the management and ZnO piglets. ZnO and flavonoid therapy elevated the expression of TAS2R39, whereas ZnO pigs additionally expressed higher TAS2R16 than management within the gut. Flavonoid therapy improved the intestine perform, probably explaining a better efficiency on the finish of the nursery interval.


Consequently, citrus flavonoids supplementation, along with amoxicillin, is a promising different to the usage of zinc oxide plus amoxicillin and apramycin in weanling pigs, minimizing the usage of antibiotics.

Paniagua, M., Villagómez-Estrada, S., Crespo, F. J., Pérez, J. F., Arís, A., Devant, M., & Solà-Oriol, D. (2023). Citrus Flavonoids Supplementation as an Different to Change Zinc Oxide in Weanling Pigs’ Diets Minimizing the Use of Antibiotics. Animals, 13(6), 967. https://doi.org/10.3390percent2Fani13060967

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